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Article

Step-down heating enhances the cytotoxicity of human tumour necrosis factor on murine and human tumour cell lines in vitro.

International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group - 1 Jan 2000

Klostergaard J, Akimaru Y, Tomasovic S P

Abstract excerpt

The response of tumour necrosis factor (TNF)-sensitive murine L929 cells to TNF was enhanced approximately 1000-fold after step-down heating (SDH) for 30 min at a sensitizing temperature (ST) of 43 degrees C and a subsequent 24 h incubation at a test temperature (TT) of 40.5 degrees C, compared t...

Topics

Animals
Cell Line
Cell Survival
Combined Modality Therapy
Drug Resistance
Heat-Shock Proteins
Humans
Hyperthermia, Induced
Mice
Neoplasms
Neoplasms, Experimental

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Phenotype

Temperature

Tumor Cells, Cultured

Tumor Necrosis Factor-alpha

Tumor Stem Cell Assay

Source

Identifiers

PMID: 8676012
DOI: 10.3109/02656739609023693

Genes

TNF
DLD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8676012-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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