Article
Selection of tumor cell variants for resistance to tumor necrosis factor also induces a form of pleiotropic drug resistance.
Cancer immunology, immunotherapy : CII - 1 Jan 1992
Wright S C, Tam A W, Kumar P
Abstract excerpt
This study has addressed the question of whether there may be some common mechanism underlying the induction or expression of acquired cytokine and drug resistance in a tumor cell line. This study employed the tumor-necrosis-factor(TNF)-sensitive U937 tumor cell line as a model system to determine if selection of a tumor cell variant for cytokine resistance would also result in drug resistance and vice versa....
Topics
- Animals
- Antineoplastic Agents
- Colchicine
- Cytokines
- Cytotoxicity, Immunologic
- Drug Resistance
- Fibrosarcoma
- Genetic Variation
- Humans
- Immunity, Cellular
- Lymphoma, Large B-Cell, Diffuse