Article
Different malignant phenotypes induced in a stable, subdiploid, benign epithelial clone by DNA transfection.
Anticancer research - 1 Jan 2000
Gibbins J R, Nicholson T R, Vozab R J, Ying B, Messerle K R
Abstract excerpt
Progression to malignancy in carcinomas has been studied in a stable, benign, subdiploid, cloned epithelial cell line (A5P/B10) sensitive to Geneticin at 100 micrograms/ml. A total of 28 cell lines were selected for Geneticin - resistance and inoculated into the footpads of syngeneic animals following co-transfection with pSV2neo and genomic DNA, or transfection with plasmid constructs containing neo and the...
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