Loss of the metastatic phenotype by a human epidermoid carcinoma cell line, HEp-3, is accompanied by increased expression of tissue inhibitor of metalloproteinase 2.

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Article

Loss of the metastatic phenotype by a human epidermoid carcinoma cell line, HEp-3, is accompanied by increased expression of tissue inhibitor of metalloproteinase 2.

Cancer research - 15 Oct 1992

Testa J E

Abstract excerpt

The human epidermoid carcinoma cell line HEp-3 gives rise to spontaneous metastases in nude mice and in the chick chorioallantoic membrane (CAM) assay system. Cells passaged continuously on the CAM retain their ability to form metastases, while cells carried in vitro lose metastatic potential with time. A HEp-3 cell line derived from a highly metastatic CAM tumor was grown continuously in vitro for 16 weeks. At...

Topics

Allantois
Animals
Carcinoma, Squamous Cell
Chick Embryo
Chorion
Collagenases
Humans
Liver Neoplasms
Metalloendopeptidases
Neoplasm Metastasis
Neoplasm Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Phenotype

Receptors, Cell Surface

Receptors, Urokinase Plasminogen Activator

Tissue Inhibitor of Metalloproteinase-2

Tumor Cells, Cultured

Urokinase-Type Plasminogen Activator

Source

Open in PubMed

Identifiers

PMID: 1327511

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1327511-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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