Detection and characterization of low abundance cellular proteins that specifically increase upon loss of the metastatic phenotype.

doi:10.1002/jcb.240510214

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Article

Detection and characterization of low abundance cellular proteins that specifically increase upon loss of the metastatic phenotype.

Journal of cellular biochemistry - 1 Feb 1993

Nielsen-Preiss S M, Quigley J P

Abstract excerpt

Human epidermoid carcinoma (HEp-3) cells are highly tumorigenic and metastatic in vivo, but their metastatic phenotype is progressively and uniquely lost upon serial passage in vitro. The nonmetastatic phenotype is fully reversible to the highly metastatic state when HEp-3 cells are passaged back...

Topics

Animals
Carcinoma, Squamous Cell
Chick Embryo
Electrophoresis, Gel, Two-Dimensional
Electrophoresis, Polyacrylamide Gel
Gene Expression Regulation, Neoplastic
Humans
Image Processing, Computer-Assisted
Neoplasm Proteins
Phenotype
Plasminogen Activators
Tumor Cells, Cultured

Source

Open in PubMed

Identifiers

PMID: 8440754
DOI: 10.1002/jcb.240510214

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8440754-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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