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Article

Reduction in Surface Urokinase Receptor Forces Malignant Cells into a Protracted State of Dormancy

5 May 1997

Abstract excerpt

Considerable evidence links urokinase plasminogen activator (uPA) bound to its surface receptor (uPAR) with enhanced invasiveness of cancer cells. By blocking uPAR expression in human epidermoid carcinoma cells (HEp3), we have now identified an additional and novel in vivo function for this receptor by showing that receptor-deficient cells enter a state of dormancy reminiscent of that observed in human cancer...

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Identifiers

PMID: 9151680
DOI: 10.1083/jcb.137.3.767

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Reduction in Surface Urokinase Receptor Forces Malignant Cells into a Protracted State of DormancyPMID 9151680Read ↗

Loss of the metastatic phenotype by a human epidermoid carcinoma cell line, HEp-3, is accompanied by increased expression of tissue inhibitor of metalloproteinase 2.Semantic proximity Read ↗

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The receptor for urokinase-plasminogen activator (uPAR) controls plasticity of cancer cell movement in mesenchymal and amoeboid migration style.Semantic proximity Read ↗

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Addressing the Role of Cell Adhesion in Tumor Cell DormancySemantic proximity Read ↗

Decreased expression of intercellular adhesion molecule-1 (ICAM-1) and urokinase-type plasminogen activator receptor (uPAR) is associated with tumor cell spreading in vivo.Semantic proximity Read ↗

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Extracellular signal-regulated kinase functions in the urokinase receptor-dependent pathway by which neutralization of low density lipoprotein receptor-related protein promotes fibrosarcoma cell migration and matrigel invasion.Semantic proximity Read ↗

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The urokinase-type plasminogen activator system in cancer metastasis: A reviewSemantic proximity Read ↗

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