Article
What structure and function of avian plasminogen activator and matrix metalloproteinase-2 reveal about their counterpart mammalian enzymes, their regulation and their role in tumor invasion.
Enzyme & protein - 1 Jan 1996
Alexander D S, Aimes R T, Quigley J P
Abstract excerpt
Rous sarcoma virus-transformed chick embryo fibroblasts (RSVCEF) constitute a well-characterized model system for oncogenic transformation, matrix degradation, and cancer invasion. As RSVCEF cultures employ both serine protease and metalloprotease cascades in the process of matrix degradation, th...
Topics
- Amino Acid Sequence
- Animals
- Cell Transformation, Viral
- Cells, Cultured
- Chick Embryo
- Enzyme Activation
- Extracellular Matrix
- Gelatinases
- Glycoproteins
- Humans
- Matrix Metalloproteinase 2
- Metalloendopeptidases
- Mice
- Molecular Sequence Data
- Neoplasm Invasiveness
- Phenotype
- Plasminogen Activators
- Protease Inhibitors