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Article

A review of tissue inhibitor of metalloproteinases-3 (TIMP-3) and experimental analysis of its effect on primary tumor growth.

Biochemistry and cell biology = Biochimie et biologie cellulaire - 1 Jan 1996

Anand-Apte B, Bao L, Smith R, Iwata K, Olsen B R, Zetter B, Apte S S

Abstract excerpt

The family of tissue inhibitors of metalloproteinases (TIMPs) presently numbers four distinct gene products that are specific inhibitors of the matrix metalloproteinases (MMPs). The local balance between MMPs and TIMPs is believed to play a major role in extracellular matrix (ECM) remodeling during development and in diseases such as cancer and arthritis. Unlike the other TIMPs, which are soluble. TIMP-3 is...

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Identifiers

PMID: 9164653
DOI: 10.1139/o96-090

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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A review of tissue inhibitor of metalloproteinases-3 (TIMP-3) and experimental analysis of its effect on primary tumor growth.PMID 9164653Read ↗

Cancer Gene Therapy with Tissue Inhibitors of Metalloproteinases (TIMPs)Semantic proximity Read ↗

The Gene Structure of Tissue Inhibitor of Metalloproteinases (TIMP)-3 and Its Inhibitory Activities Define the Distinct TIMP Gene FamilySemantic proximity Read ↗

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Tissue inhibitors of metalloproteinases (TEMP) in invasion and proliferationSemantic proximity Read ↗

Temporal and spatial regulation of gene expression mediated by the promoter for the human tissue inhibitor of metalloproteinases-3 (TIMP-3)-encoding geneSemantic proximity Read ↗

Inhibition of fibroblast-induced angiogenic phenotype of cultured endothelial cells by the overexpression of tissue inhibitor of metalloproteinase (TIMP)-3.Semantic proximity Read ↗

Genetic aberrations in tissue inhibitor of metalloproteinases-3 lead to manifestations of the myofibroblast phenotype in mouse fibroblasts and fibroblasts of patients with Sorsby fundus dystrophy.Semantic proximity Read ↗

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Biology of Tissue Inhibitor of Metalloproteinase 3 (TIMP3), and Its Therapeutic Implications in Cardiovascular PathologySemantic proximity Read ↗

Molecular mechanisms of tissue inhibitor of metalloproteinase 2 in the tumor microenvironmentSemantic proximity Read ↗

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