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Article

p53 mutations in HPV-negative cervical carcinoma.

Oncogene - 1 Jan 1994

Park D J, Wilczynski S P, Paquette R L, Miller C W, Koeffler H P

Abstract excerpt

Human papillomavirus (HPV) infection has been strongly linked to the development of cervical carcinoma. Two viral oncoproteins, E6 and E7, produced by HPV, have been shown to immortalize primary human genital epithelial cells by interacting with the protein products of cellular tumor suppressor genes p53 and Rb, respectively. E6 binds to the cellular p53 protein promoting p53 degradation and inactivity. This...

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Identifiers

PMID: 8302581

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Source receipt: pubmed, retrieved 7 Sept 2026.

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