Article
Presence of p53 mutation in human cervical carcinomas associated with HPV-33 infection.
Anticancer research - 1 Jan 2000
Lo K W, Mok C H, Chung G, Huang D P, Wong F, Chan M, Lee J C, Tsao S W
Abstract excerpt
In this present study, we report the mutation of the p53 gene in vivo in human primary carcinomas of cervix and cervical intraepithelial neoplasia (CIN). The association of the HPV subtypes with the tumors was determined by multiplex primer polymerase chain reaction (PCR) amplification. The mutation of the p53 gene was detected using PCR amplification of the p53 exons followed by SSCP (single strand conformation...
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