Article
Association between p53 mutation and clinicopathological features of non-small cell lung cancer.
Japanese journal of clinical oncology - 1 Aug 1997
Guang S G, Ogura T, Sekine I, Yokozaki M, Esumi H, Kodama T, Nagai K
Abstract excerpt
Genetic alterations in exons 5-8 of the p53 gene, determined by single-strand conformation polymorphism and sequencing analyses, and the clinicopathological characteristics of 108 patients with non-small cell lung cancer were compared. Mutations in this gene were found in 37 of the 108 patients (34%): in 30% (23/76) of those with adenocarcinomas, 46% (12/26) of those with squamous cell, 33% (1/3) of those with...
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