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Article

A viral long terminal repeat expressed in CD4+CD8+ precursors is downregulated in mature peripheral CD4-CD8+ or CD4+CD8- T cells.

Molecular and cellular biology - 1 Aug 1992

Paquette Y, Doyon L, Laperrière A, Hanna Z, Ball J, Sekaly R P, Jolicoeur P

Abstract excerpt

The long terminal repeat from a thymotropic mouse mammary tumor virus variant, DMBA-LV, was used to drive the expression of two reporter genes, murine c-myc and human CD4, in transgenic mice. Expression was observed specifically in thymic immature cells. Expression of c-myc in these cells induced oligoclonal CD4+ CD8+ T-cell thymomas. Expression of human CD4 was restricted to thymic progenitor CD4- CD8- and CD4+...

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Source

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Identifiers

PMID: 1321339
DOI: 10.1128/mcb.12.8.3522-3530.1992
PMCID: PMC364609

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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