Article
A viral long terminal repeat expressed in CD4+CD8+ precursors is downregulated in mature peripheral CD4-CD8+ or CD4+CD8- T cells.
Molecular and cellular biology - 1 Aug 1992
Paquette Y, Doyon L, Laperrière A, Hanna Z, Ball J, Sekaly R P, Jolicoeur P
Abstract excerpt
The long terminal repeat from a thymotropic mouse mammary tumor virus variant, DMBA-LV, was used to drive the expression of two reporter genes, murine c-myc and human CD4, in transgenic mice. Expression was observed specifically in thymic immature cells. Expression of c-myc in these cells induced...
Topics
- Animals
- Antibodies, Monoclonal
- Antisense Elements (Genetics)
- CD4 Antigens
- CD8 Antigens
- Flow Cytometry
- Genes, myc
- Humans
- Mammary Tumor Virus, Mouse
- Mice
- Mice, Nude
- Mice, Transgenic
- Phenotype
- RNA Probes
- Repetitive Sequences, Nucleic Acid