Article
Evidence for distinct CD4 silencer functions at different stages of thymocyte differentiation.
Molecular cell - 1 Nov 2002
Taniuchi Ichiro, Sunshine Mary Jean, Festenstein Richard, Littman Dan R
Abstract excerpt
An intronic silencer within the CD4 gene is the critical cis regulatory element for T cell subset-specific expression of CD4. We have combined transfection studies with gene targeting in mice to identify several key sequences within the silencer core that are required for gene silencing during thymocyte development. In mice, mutations in individual sites resulted in variegated, but heritable, derepression of CD4...
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