Article
The immature thymocyte is protected from N-methylnitrosourea-induced lymphoma by the human MGMT-CD2 transgene.
Carcinogenesis - 1 May 1995
Zaidi N H, Allay E, Ayi T C, Li B F, Dumenco L L, Sy M S, Gerson S L
Abstract excerpt
N-methylnitrosourea (MNU) induces thymic lymphoma in a high proportion of susceptible C57BL/6xSJL (C57/SJL) mice. Expression of the human DNA repair gene, MGMT cDNA, which encodes O6-methylguanine-DNA-methyltransferase, in transgenic mice effectively prevents MNU-induced thymic lymphomas. In this...
Topics
- Animals
- Antigens, CD
- CD2 Antigens
- Crosses, Genetic
- Humans
- In Situ Hybridization
- Lymphoma
- Methylnitrosourea
- Methyltransferases
- Mice
- Mice, Inbred C57BL
- Mice, Inbred Strains
- Mice, Transgenic
- O(6)-Methylguanine-DNA Methyltransferase
- Phenotype
- RNA, Messenger
- Recombinant Fusion Proteins
- T-Lymphocytes