Article
Identification and characterization of a human CD4 silencer.
European journal of immunology - 1 Feb 1996
Donda A, Schulz M, Bürki K, De Libero G, Uematsu Y
Abstract excerpt
Using transgenic mice, we have identified a human CD4 silencer contained within a 484-bp fragment in the first intron of the CD4 gene. Further experiments have mapped a lineage-specific silencing activity to a region of 190 bp. This region contains two protein-binding sites detected by deoxyribon...
Topics
- Animals
- Base Sequence
- CD4 Antigens
- CD8-Positive T-Lymphocytes
- DNA Footprinting
- Genes, Regulator
- Humans
- Mice
- Mice, Inbred C57BL
- Mice, Transgenic
- Molecular Sequence Data
- Mutation
- Protein Binding
- Regulatory Sequences, Nucleic Acid
- Sequence Homology, Nucleic Acid
- Transfection
- Transgenes