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Article

cis-dominant regulation of CD4 and CD8 gene expression in rat/mouse T cell heterohybridomas.

Journal of immunology (Baltimore, Md. : 1950) - 15 Mar 1993

Gocinski B L, Sun D, Coleclough C

Abstract excerpt

To determine whether expression of CD4 and CD8 molecules on T cells is determined-solely by transacting regulators, we examined heterohybridomas derived from the fusion of a rat CD4+ T cell line and the CD4- CD8- mouse thymoma BW5147. The majority of hybrid offspring expressed rat CD4. However, a fraction of the cell lines obtained expressed not only rat CD4 but also various amounts of mouse CD4 and CD8 molecules...

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PMID: 8450209

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