Article
A general approach for controlling transcription and probing epigenetic mechanisms: application to the CD4 locus.
Journal of immunology (Baltimore, Md. : 1950) - 15 Jan 2013
Wan Mimi, Kaundal Ravinder, Huang Haichang, Zhao Jiugang, Yang Xiaojun, Chaiyachati Barbara H, Li Sicong, Chi Tian
Abstract excerpt
Synthetic regulatory proteins such as tetracycline (tet)-controlled transcription factors are potentially useful for repression as well as ectopic activation of endogenous genes and also for probing their regulatory mechanisms, which would offer a versatile genetic tool advantageous over conventional gene targeting methods. In this study, we provide evidence supporting this concept using Cd4 as a model. CD4 is...
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