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Article

Clonal deletion of V beta 14-bearing T cells in mice transgenic for mammary tumour virus.

Nature - 21 Mar 1991

Acha-Orbea H, Shakhov A N, Scarpellino L, Kolb E, Müller V, Vessaz-Shaw A, Fuchs R, Blöchlinger K, Rollini P, Billotte J

Abstract excerpt

Autoreactive T lymphocytes are clonally deleted during maturation in the thymus. Deletion of T cells expressing particular receptor V beta elements is controlled by poorly defined autosomal dominant genes. A gene has now been identified by expression of transgenes in mice which causes deletion of...

Topics

Amino Acid Sequence
Animals
Chromosome Deletion
Electrophoresis, Polyacrylamide Gel
Female
Genes, Viral
Mammary Tumor Virus, Mouse
Mice
Mice, Transgenic
Molecular Sequence Data
Open Reading Frames

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Phenotype

Proviruses

Receptors, Antigen, T-Cell

T-Lymphocytes

Source

Identifiers

PMID: 1848685
DOI: 10.1038/350207a0

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-1848685-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Click a neighbor to travelStep 1 · 12 closest

Clonal deletion of V beta 14-bearing T cells in mice transgenic for mammary tumour virus.PMID 1848685Read ↗

T cell receptor V beta repertoire in mice lacking endogenous mouse mammary tumor provirus.Semantic proximity Read ↗

Molecular and genetic parameters defining T‐cell clonal selectionSemantic proximity Read ↗

A viral long terminal repeat expressed in CD4+CD8+ precursors is downregulated in mature peripheral CD4-CD8+ or CD4+CD8- T cells.Semantic proximity Read ↗

Lower receptor avidity required for thymic clonal deletion than for effector T-cell function.Semantic proximity Read ↗

Direct evidence for the role of COOH terminus of mouse mammary tumor virus superantigen in determining T cell receptor V beta specificity.Semantic proximity Read ↗

Apparent bypass of negative selection in CD8+ tumours in CD2-myc transgenic mice.Semantic proximity Read ↗

Selective silencing of full-length CD80 but not IgV-CD80 leads to impaired clonal deletion of self-reactive T cells and altered regulation of immune responses.Semantic proximity Read ↗

Abrogation of the allelic exclusion in a T cell receptor beta chain gene transgenic mouse strain.Semantic proximity Read ↗

Functional analysis of T cells lacking germline-encoded complementarity-determining regionsSemantic proximity Read ↗

V(D)J recombination and allelic exclusion of a TCR beta-chain minilocus occurs in the absence of a functional promoter.Semantic proximity Read ↗

Dominant expression of a distinctive V14+ T-cell antigen receptor alpha chain in mice.Semantic proximity Read ↗

Autoreactive T cells escape clonal deletion in the thymus by a CD24-dependent pathway.Semantic proximity Read ↗

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