Article
Clonal deletion of V beta 14-bearing T cells in mice transgenic for mammary tumour virus.
Nature - 21 Mar 1991
Acha-Orbea H, Shakhov A N, Scarpellino L, Kolb E, Müller V, Vessaz-Shaw A, Fuchs R, Blöchlinger K, Rollini P, Billotte J
Abstract excerpt
Autoreactive T lymphocytes are clonally deleted during maturation in the thymus. Deletion of T cells expressing particular receptor V beta elements is controlled by poorly defined autosomal dominant genes. A gene has now been identified by expression of transgenes in mice which causes deletion of V beta 14+ T cells. The gene lies in the open reading frame of the long terminal repeat of the mouse mammary tumour virus.
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