Deviated overexpression of TCR-beta, TCR-gamma, CD4, and CD8 on thymic lymphomas induced by 1-propyl-1-nitrosourea: destruction of the allelic exclusion of TCR-beta and expression of functional TCR-betagamma heterodimer on a lymphoma, cFTL53.

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Article

Deviated overexpression of TCR-beta, TCR-gamma, CD4, and CD8 on thymic lymphomas induced by 1-propyl-1-nitrosourea: destruction of the allelic exclusion of TCR-beta and expression of functional TCR-betagamma heterodimer on a lymphoma, cFTL53.

Journal of immunology (Baltimore, Md. : 1950) - 15 Jul 1997

Kinebuchi M, Matsuura A, Ogiu T, Kikuchi K

Abstract excerpt

Thymic lymphomas (FTLs) induced by the chemical carcinogen 1-propyl-1-nitrosourea (PNU) in F344 rats showed deviated overexpression of TCR-beta, TCR-gamma, CD4, and CD8. Even though most FTLs were in the CD4+ CD8+ stage, all FTLs expressed TCR-beta mRNA with TCR-gamma mRNA, but without TCR-alpha...

Topics

Alleles
Amino Acid Sequence
Animals
Base Sequence
CD4 Antigens
CD8 Antigens
Dimerization
Gene Expression Regulation, Neoplastic
Lymphoma
Molecular Sequence Data
Nitrosourea Compounds
Rats
Rats, Inbred F344
Receptors, Antigen, T-Cell, alpha-beta

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Open in PubMed

Identifiers

PMID: 9218591

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9218591-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Receptors, Antigen, T-Cell, gamma-delta

Thymus Neoplasms