Article
Disruption of a silencer domain by a retrotransposon.
Genetics - 1 Jul 1992
Mastrangelo M F, Weinstock K G, Shafer B K, Hedge A M, Garfinkel D J, Strathern J N
Abstract excerpt
A galactose-inducible Ty element carrying the HIS3 gene has been used as an insertional mutagen to generate alpha-factor resistant mutants. This collection of Ty-induced mutations includes insertions into the gene for the alpha-factor receptor (STE2), several nonspecific STE genes, and mutations that lead to the expression of the normally silent HML alpha locus. The hml alpha "on" mutations fall into two classes,...
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