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Article

The DAF2-2 mutation, a dominant inhibitor of the STE4 step in the alpha-factor signaling pathway of Saccharomyces cerevisiae MAT alpha cells.

Genetics - 1 Oct 1990

Cross F R

Abstract excerpt

A dominant mutation (DAF2-2) resulting in resistance to the mating pheromone alpha-factor in Saccharomyces cerevisiae MATa cells was identified and characterized genetically. Whereas wild-type cells induce a high level of the FUS1 mRNA from a low baseline on exposure to alpha-factor, DAF2-2 cells...

Topics

Alleles
Drug Resistance, Microbial
Epistasis, Genetic
Gene Expression Regulation, Fungal
Genes, Fungal
Mating Factor
Mutation
Peptides
Phenotype
Pheromones
Saccharomyces cerevisiae
Signal Transduction

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Identifiers

PMID: 2245911
DOI: 10.1093/genetics/126.2.301
PMCID: PMC1204184

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-2245911-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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