Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The DAF2-2 mutation, a dominant inhibitor of the STE4 step in the alpha-factor signaling pathway of Saccharomyces cerevisiae MAT alpha cells.

Genetics - 1 Oct 1990

Cross F R

Abstract excerpt

A dominant mutation (DAF2-2) resulting in resistance to the mating pheromone alpha-factor in Saccharomyces cerevisiae MATa cells was identified and characterized genetically. Whereas wild-type cells induce a high level of the FUS1 mRNA from a low baseline on exposure to alpha-factor, DAF2-2 cells were constitutive producers of an intermediate level of FUS1 RNA; the level was increased only modestly by...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alleles
Share to Drug Resistance, Microbial
Share to Gene Expression Regulation, Fungal

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genes, Fungal

Share to Mutation

Share to Phenotype

Share to Saccharomyces cerevisiae

Share to Signal Transduction

Source

Open in PubMed Open full text

Identifiers

PMID: 2245911
DOI: 10.1093/genetics/126.2.301
PMCID: PMC1204184

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The DAF2-2 mutation, a dominant inhibitor of the STE4 step in the alpha-factor signaling pathway of Saccharomyces cerevisiae MAT alpha cells.PMID 2245911Read ↗

The pheromone receptors inhibit the pheromone response pathway in Saccharomyces cerevisiae by a process that is independent of their associated G alpha protein.Semantic proximity Read ↗

Autocrine activation of the pheromone response pathway in matalpha2- cells is attenuated by SST2- and ASG7-dependent mechanisms.Semantic proximity Read ↗

Prevalence, distribution, and mechanisms of genetic dominance in the yeast mating pathway.Semantic proximity Read ↗

Rst1 and Rst2 are required for the a/alpha diploid cell type in yeast.Semantic proximity Read ↗

The C terminus of the Saccharomyces cerevisiae alpha-factor receptor contributes to the formation of preactivation complexes with its cognate G protein.Semantic proximity Read ↗

Relative contributions of MCM1 and STE12 to transcriptional activation of a- and alpha-specific genes from Saccharomyces cerevisiae.Semantic proximity Read ↗

Receptor inhibition of pheromone signaling is mediated by the Ste4p Gbeta subunit.Semantic proximity Read ↗

Identification and characterization of a mutation affecting the division arrest signaling of the pheromone response pathway in Saccharomyces cerevisiae.Semantic proximity Read ↗

Inhibition of glycogen synthesis in Saccharomyces cerevisiae by the mating pheromone alpha-factor.Semantic proximity Read ↗

Functional and physical interactions among Saccharomyces cerevisiae α-factor receptors.Semantic proximity Read ↗

The yeast SFL2 gene may be necessary for mating-type control.Semantic proximity Read ↗

Disruption of receptor-G protein coupling in yeast promotes the function of an SST2-dependent adaptation pathway.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.