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Article

Transcription of alpha-specific genes in Saccharomyces cerevisiae: DNA sequence requirements for activity of the coregulator alpha 1.

Molecular and cellular biology - 1 Nov 1993

Hagen D C, Bruhn L, Westby C A, Sprague G F

Abstract excerpt

Transcription activation of alpha-specific genes in Saccharomyces cerevisiae is regulated by two proteins, MCM1 and alpha 1, which bind to DNA sequences, called P'Q elements, found upstream of alpha-specific genes. Neither MCM1 nor alpha 1 alone binds efficiently to P'Q elements. Together, however, they bind cooperatively in a manner that requires both the P' sequence, which is a weak binding site for MCM1, and...

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Identifiers

PMID: 8413280
DOI: 10.1128/mcb.13.11.6866-6875.1993
PMCID: PMC364749

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