Article
Expression of p53 protein in invasive colorectal carcinomas of different histologic types.
Cancer - 15 Dec 1992
Hanski C, Bornhoeft G, Shimoda T, Hanski M L, Lane D P, Stein H, Riecken E O
Abstract excerpt
BACKGROUND: This study was performed to determine whether morphologic differences of colonic cancer types can be related to different genotypes of these tumors. METHODS: Paraffin sections of 76 human invasive colorectal carcinomas were examined for the overexpression of p53 oncoprotein with the avidin-biotin complex-peroxidase staining procedure and CM-1 antiserum, which detects p53 protein in paraffin-embedded...
Topics
- Adenoma
- Animals
- Carcinoma
- Cell Nucleus
- Colorectal Neoplasms
- Epithelium
- Gene Expression
- Genotype
- Humans
- Immunohistochemistry
- Intestinal Mucosa
- Mutation