Article
Malignant transformation of NIH-3T3 cells after subcutaneous co-injection with a reconstituted basement membrane (matrigel).
International journal of cancer - 9 Jul 1992
Fridman R, Sweeney T M, Zain M, Martin G R, Kleinman H K
Abstract excerpt
NIH-3T3 cells are non-tumorigenic when injected into athymic mice. If these cells are mixed with an extract of basement-membrane proteins (matrigel) and injected s.c., they form locally invasive and highly vascularized tumors. Cells cultured from the NIH-3T3-matrigel-induced tumors showed a trans...
Topics
- Animals
- Cell Line, Transformed
- Cell Transformation, Neoplastic
- Collagen
- Drug Combinations
- Laminin
- Lung Neoplasms
- Matrix Metalloproteinase 9
- Mice
- Mice, Nude
- Microbial Collagenase
- Neoplasm Metastasis
- Neoplasm Transplantation
- Neoplasms, Experimental
- Phenotype
- Proteoglycans
- Tumor Cells, Cultured