Article
Lack of suppression of tumor cell phenotype by overexpression of TIMP-3 in mouse JB6 tumor cells identification of a transfectant with increased tumorigenicity and invasiveness.
Anticancer research - 1 Jan 2000
Sun Y, Kim H, Parker M, Stetler-Stevenson W G, Colburn N H
Abstract excerpt
BACKGROUND: We have recently cloned mouse tissue inhibitor of metalloproteinases-3 (mTIMP-3) by the differential display technique and found that mTIMP-3 was expressed in preneoplastic but not in neoplastic mouse JB6 epidermal cells (Sun et at. Cancer Res. 54:11139, 1994). This down regulation of the gene is attributable at least in part to alteration in gene methylation (Sun et al., J. Biol. Chem., 270:19312,...
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