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Article

Spontaneous acquisition of tumorigenicity and invasiveness by mouse lens explant cells during culture in vitro.

In vitro cellular & developmental biology : journal of the Tissue Culture Association - 1 May 1991

Messiaen L, Qian S, De Bruyne G, Boghaert E, Moens T, Rabaey M, Van Roy F, Mareel M

Abstract excerpt

The lens of the eye is one of the rare organs in which tumors do not occur spontaneously. It therefore appeared to us that lens cells would not present the background of spontaneous transformation toward malignancy found with many other cell cultures. We have cultured C3H/HeA mouse lens explant (MLE) cells for 70 wk and analyzed changes in malignancy-related phenotypes in function of the number of passages. In...

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Identifiers

PMID: 2071540
DOI: 10.1007/BF02630956

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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