Article
Cells transfected with the basic fibroblast growth factor gene fused to a signal sequence are invasive in vitro and in situ in the brain.
Neurosurgery - 1 Apr 1995
Gately S, Tsanaclis A M, Takano S, Klagsbrun M, Brem S
Abstract excerpt
Invasiveness is a critical event in the development of malignancy in brain tumors. A potential molecular mediator is basic fibroblast growth factor (bFGF). NIH-3T3 cells transfected with the bFGF gene fused with a signal peptide sequence (signal peptide bFGF) acquire an invasive phenotype as meas...
Topics
- 3T3 Cells
- Animals
- Brain Neoplasms
- Cell Movement
- Cell Transformation, Neoplastic
- Collagenases
- Fibroblast Growth Factor 2
- Mice
- Mice, Nude
- Molecular Weight
- Neoplasm Invasiveness
- Neoplasm Transplantation