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Article

Invasive human fibrosarcoma DNA mediated induction of a 92 kDa gelatinase/type IV collagenase leads to an invasive phenotype.

Biochemical and biophysical research communications - 31 Dec 1991

Kubota S, Mitsudomi T, Yamada Y

Abstract excerpt

Proteolytic enzymes, such as gelatinase/type IV collagenase, play a pivotal role in cancer invasion and metastasis. Invasive human fibrosarcoma cells (HT1080) secrete two species of gelatinase/type IV collagenase, 68-72 kDa and 92 kDa enzymes. The purpose of this study is to elucidate which species of gelatinase/type IV collagenase plays a more important role in invasion. We have found that HT1080 x human...

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PMID: 1662501
DOI: 10.1016/0006-291x(91)92114-y

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