Invasive human fibrosarcoma DNA mediated induction of a 92 kDa gelatinase/type IV collagenase leads to an invasive phenotype.

doi:10.1016/0006-291x(91)92114-y

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Invasive human fibrosarcoma DNA mediated induction of a 92 kDa gelatinase/type IV collagenase leads to an invasive phenotype.

Biochemical and biophysical research communications - 31 Dec 1991

Kubota S, Mitsudomi T, Yamada Y

Abstract excerpt

Proteolytic enzymes, such as gelatinase/type IV collagenase, play a pivotal role in cancer invasion and metastasis. Invasive human fibrosarcoma cells (HT1080) secrete two species of gelatinase/type IV collagenase, 68-72 kDa and 92 kDa enzymes. The purpose of this study is to elucidate which species of gelatinase/type IV collagenase plays a more important role in invasion. We have found that HT1080 x human...

Topics

Animals
Base Sequence
Basement Membrane
Blotting, Southern
Cell Line
DNA, Neoplasm
Enzyme Induction
Fibrosarcoma
Gelatinases
Genes, ras
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Hybrid Cells

Mice

Mice, Inbred C3H

Microbial Collagenase

Molecular Sequence Data

Molecular Weight

Neoplasm Invasiveness

Source

Open in PubMed

Identifiers

PMID: 1662501
DOI: 10.1016/0006-291x(91)92114-y

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1662501-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Invasive human fibrosarcoma DNA mediated induction of a 92 kDa gelatinase/type IV collagenase leads to an invasive phenotype.PMID 1662501Read ↗

Marked acceleration of the metastatic phenotype of a rat bladder carcinoma cell line by the expression of human gelatinase A.Semantic proximity Read ↗

Mr 92,000 gelatinase release correlates with the metastatic phenotype in transformed rat embryo cells.Semantic proximity Read ↗

Matrix metalloproteinases and tissue inhibitors of metalloproteinases in human gliomasSemantic proximity Read ↗

The invasive phenotype in HMT-3522 cells requires increased EGF receptor signaling through both PI 3-kinase and ERK 1,2 pathways.Semantic proximity Read ↗

Induction of fibroblast 92 kDa gelatinase/type IV collagenase expression by direct contact with metastatic tumor cells.Semantic proximity Read ↗

Selective incorporation of fibronectin isoforms into the extracellular matrix of hybrids between human fibrosarcoma cells and normal human fibroblasts.Semantic proximity Read ↗

Complete structure of the human gene for 92-kDa type IV collagenase. Divergent regulation of expression for the 92- and 72-kilodalton enzyme genes in HT-1080 cells.Semantic proximity Read ↗

Infiltration of neutrophils is required for acquisition of metastatic phenotype of benign murine fibrosarcoma cells: implication of inflammation-associated carcinogenesis and tumor progression.Semantic proximity Read ↗

Basic Fibroblast Growth Factor Regulates Matrix Metalloproteinases Production and In Vitro Invasiveness in Human Bladder Cancer Cell LinesSemantic proximity Read ↗

Malignant transformation of NIH-3T3 cells after subcutaneous co-injection with a reconstituted basement membrane (matrigel).Semantic proximity Read ↗

Defining the invasive phenotype of proximal gastric cancer cells.Semantic proximity Read ↗

Cells transfected with the basic fibroblast growth factor gene fused to a signal sequence are invasive in vitro and in situ in the brain.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.