Article
Induction of fibroblast 92 kDa gelatinase/type IV collagenase expression by direct contact with metastatic tumor cells.
Journal of cell science - 1 Feb 1994
Himelstein B P, Canete-Soler R, Bernhard E J, Muschel R J
Abstract excerpt
Previous studies have correlated release of the 92 kDa type IV collagenase/gelatinase by tumor cells in culture with metastatic potential. We have now demonstrated that the ability of tumor cells that do not express the 92 kDa gelatinase to induce release of this metalloproteinase from normal fib...
Topics
- Animals
- Cell Adhesion
- Cell Communication
- Cell Line, Transformed
- Collagenases
- Fibroblasts
- Gene Expression
- In Situ Hybridization
- Matrix Metalloproteinase 9
- Mice
- Mice, Nude
- Neoplasm Metastasis
- Phenotype
- Rats
- Tumor Cells, Cultured