Article
Genotypic and phenotypic characterization of human immunodeficiency virus type 1 variants isolated from AIDS patients after prolonged adefovir dipivoxil therapy.
Antimicrobial agents and chemotherapy - 1 Jul 1998
Mulato A S, Lamy P D, Miller M D, Li W X, Anton K E, Hellmann N S, Cherrington J M
Abstract excerpt
Adefovir dipivoxil [bis(pivaloyloxymethyl)-ester prodrug], an orally bioavailable prodrug of adefovir [9-(2-phosphonylmethoxyethyl)adenine], is currently in phase III clinical trials for the treatment of human immunodeficiency virus (HIV). In vitro experiments demonstrated that either a K65R or a...
Topics
- Acquired Immunodeficiency Syndrome
- Adenine
- Anti-HIV Agents
- Drug Resistance, Microbial
- Genotype
- HIV Reverse Transcriptase
- HIV-1
- Humans
- Mutation
- Organophosphonates
- Phenotype
- Recombination, Genetic
- Viral Load
- Zidovudine