Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Viral DNA polymerase mutations associated with drug resistance in human cytomegalovirus.

The Journal of infectious diseases - 1 Jul 2003

Chou Sunwen, Lurain Nell S, Thompson Kenneth D, Miner Richard C, Drew W Lawrence

Abstract excerpt

Certain mutations in the viral DNA polymerase (pol) gene are known to confer drug resistance when transferred to susceptible human cytomegalovirus (CMV) strains, whereas other putative resistance mutations remain unproven. A new marker-transfer technique was used to produce recombinant CMV strains, to determine the drug susceptibility phenotypes conferred by 10 pol mutations (9 observed in clinical isolates)....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Mutation
Share to Antiviral Agents
Share to Cytomegalovirus

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA-Directed DNA Polymerase

Share to Drug Resistance, Viral

Share to Ganciclovir

Share to Phenotype

Share to Virus Replication

Source

Identifiers

PMID: 12825168
DOI: 10.1086/375743

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Viral DNA polymerase mutations associated with drug resistance in human cytomegalovirus.PMID 12825168Read ↗

Contrasting drug resistance phenotypes resulting from cytomegalovirus DNA polymerase mutations at the same exonuclease locus.Semantic proximity Read ↗

Multidrug resistance conferred by novel DNA polymerase mutations in human cytomegalovirus isolates.Semantic proximity Read ↗

Drug-resistant cytomegalovirus: clinical implications of specific mutations.Semantic proximity Read ↗

Phenotypic diversity of cytomegalovirus DNA polymerase gene variants observed after antiviral therapy.Semantic proximity Read ↗

Phenotyping of cytomegalovirus drug resistance mutations by using recombinant viruses incorporating a reporter gene.Semantic proximity Read ↗

Antiviral Drug Resistance of Human CytomegalovirusSemantic proximity Read ↗

Recombinant phenotyping of cytomegalovirus UL97 kinase sequence variants for ganciclovir resistance.Semantic proximity Read ↗

Growth and drug resistance phenotypes resulting from cytomegalovirus DNA polymerase region III mutations observed in clinical specimens.Semantic proximity Read ↗

Antiviral drug resistance in human cytomegalovirus.Semantic proximity Read ↗

A point mutation in the human cytomegalovirus DNA polymerase gene selected in vitro by cidofovir confers a slow replication phenotype in cell culture.Semantic proximity Read ↗

Cytomegalovirus: genetics of drug resistance.Semantic proximity Read ↗

Selection and recombinant phenotyping of a novel CMX001 and cidofovir resistance mutation in human cytomegalovirus.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.