Multiple cis- and trans-acting elements mediate the transcriptional response to phorbol esters.

doi:10.1038/329648a0

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Article

Multiple cis- and trans-acting elements mediate the transcriptional response to phorbol esters.

Nature - 1 Jan 2000

Chiu R, Imagawa M, Imbra R J, Bockoven J R, Karin M

Abstract excerpt

Protein kinase C is important in the transduction of signals generated at the plasma membrane. The physiological activators of protein kinase C are diacylglycerols, and the tumour-promoting phorbol esters, such as 12-O-tetradecanoyl-phorbol-14 acetate (TPA), constitute another group of specific a...

Topics

Base Sequence
Cell Line
Deoxyribonuclease I
Enhancer Elements, Genetic
Gene Expression Regulation
Humans
Mutation
Phorbol Esters
Protein Kinase C
Proto-Oncogenes
Simian virus 40
Tetradecanoylphorbol Acetate
Transcription, Genetic

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