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Article

Multiple cis- and trans-acting elements mediate the transcriptional response to phorbol esters.

Nature - 1 Jan 2000

Chiu R, Imagawa M, Imbra R J, Bockoven J R, Karin M

Abstract excerpt

Protein kinase C is important in the transduction of signals generated at the plasma membrane. The physiological activators of protein kinase C are diacylglycerols, and the tumour-promoting phorbol esters, such as 12-O-tetradecanoyl-phorbol-14 acetate (TPA), constitute another group of specific activators. Many cellular substrates for phosphorylation by protein kinase C have been described, but proteins that...

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PMID: 2821407
DOI: 10.1038/329648a0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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