Article
v-raf confers CSF-1 independent growth to a macrophage cell line and leads to immediate early gene expression without MAP-kinase activation.
Oncogene - 1 Dec 1993
Büscher D, Dello Sbarba P, Hipskind R A, Rapp U R, Stanley E R, Baccarini M
Abstract excerpt
The BAC-1.2F5 macrophage cell line depends on CSF-1 for proliferation and survival. Phosphorylation and activation of the RAF-1 kinase are among the early events in CSF-1 signal transduction. To characterize the role of RAF-1 in CSF-1-induced proliferation, we overexpressed oncogenically activate...
Topics
- Amino Acid Sequence
- Animals
- Blotting, Northern
- Blotting, Western
- Calcium-Calmodulin-Dependent Protein Kinases
- Cell Differentiation
- Cell Division
- Cell Line
- Cell Survival
- DNA
- Enzyme Activation
- Gene Expression Regulation
- Genes, Immediate-Early
- Growth Substances
- Humans
- Macrophage Colony-Stimulating Factor
- Macrophages
- Molecular Sequence Data