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Article

Biochemical consequences of the cardiofunk (R177H) mutation in yeast actin.

The Journal of biological chemistry - 28 Nov 2003

Wen Kuo-Kuang, Rubenstein Peter A

Abstract excerpt

The zebrafish cardiofunk actin mutation, R177H, causes abnormal heart development. We have introduced this mutation into yeast actin to assess its biochemical consequences. R177H G-actin exhibited reduced thermal stability and an accelerated nucleotide exchange rate. R177H actin has an increased critical concentration and polymerizes with a greatly extended nucleation phase but a faster elongation process,...

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PMID: 13129918
DOI: 10.1074/jbc.M308980200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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