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Article

Dual roles of Gln137 of actin revealed by recombinant human cardiac muscle alpha-actin mutants.

The Journal of biological chemistry - 25 Jul 2008

Iwasa Mitsusada, Maeda Kayo, Narita Akihiro, Maéda Yuichiro, Oda Toshiro

Abstract excerpt

The actin filament is quite dynamic in the cell. To determine the relationship between the structure and the dynamic properties of the actin filament, experiments using actin mutants are indispensable. We focused on Gln(137) to understand the relationships between two activities: the conformational changes relevant to the G- to F-actin transition and the activation of actin ATPase upon actin polymerization. To...

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Identifiers

PMID: 18515362
DOI: 10.1074/jbc.M800570200
PMCID: PMC3258932

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Source receipt: pubmed, retrieved 7 Sept 2026.

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