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Article

Mutations in the E. coli Rep helicase increase the amount of DNA per cell.

FEMS microbiology letters - 12 Sept 2003

Trun Nancy

Abstract excerpt

The mbrA4 mutation confers camphor resistance, severe growth defects and up to a two-fold increase in the amount of chromosomal DNA per cell. The extra DNA is replicated from oriC in a synchronous fashion. Cells containing mbrA4 are more resistant to X-rays, indicating that the extra DNA represents complete or nearly complete chromosomes. I report here that mbrA4 is an unusual allele of the leading strand DNA...

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Identifiers

PMID: 13129626
DOI: 10.1016/S0378-1097(03)00595-0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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