Article
Rep provides a second motor at the replisome to promote duplication of protein-bound DNA.
Molecular cell - 25 Nov 2009
Guy Colin P, Atkinson John, Gupta Milind K, Mahdi Akeel A, Gwynn Emma J, Rudolph Christian J, Moon Peter B, van Knippenberg Ingeborg C, Cadman Chris J, Dillingham Mark S, Lloyd Robert G, McGlynn Peter
Abstract excerpt
Nucleoprotein complexes present challenges to genome stability by acting as potent blocks to replication. One attractive model of how such conflicts are resolved is direct targeting of blocked forks by helicases with the ability to displace the blocking protein-DNA complex. We show that Rep and UvrD each promote movement of E. coli replisomes blocked by nucleoprotein complexes in vitro, that such an activity is...
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