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Article

Essential bacterial helicases that counteract the toxicity of recombination proteins.

The EMBO journal - 17 Jun 2002

Petit Marie-Agnès, Ehrlich Dusko

Abstract excerpt

PcrA, Rep and UvrD are three closely related bacterial helicases with a DExx signature. PcrA is encoded by Gram-positive bacteria and is essential for cell growth. Rep and UvrD are encoded by Gram-negative bacteria, and mutants lacking both helicases are also not viable. To understand the non-viability of the helicase mutants, we characterized spontaneous extragenic suppressors of a Bacillus subtilis pcrA null...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 12065426
DOI: 10.1093/emboj/cdf317
PMCID: PMC126070

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Source receipt: pubmed, retrieved 7 Sept 2026.

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Essential bacterial helicases that counteract the toxicity of recombination proteins.PMID 12065426Read ↗

UvrD helicase, unlike Rep helicase, dismantles RecA nucleoprotein filaments in Escherichia coli.Semantic proximity Read ↗

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Differential requirement for RecFOR pathway components in Thermus thermophilus.Semantic proximity Read ↗

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