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Histopathologic and genetic alterations as predictors of response to treatment and survival in lung cancer: a review of published data.

Critical reviews in oncology/hematology - 1 Aug 2010

Mountzios Giannis, Dimopoulos Meletios-Athanassios, Soria Jean-Charles, Sanoudou Despina, Papadimitriou Christos A

Abstract excerpt

Lung carcinogenesis is considered to be the result of composite environmental, genetic and epigenetic changes. Despite the fact that many of the genetic alterations, including loss of heterozygocity in the 3p chromosome locus and point mutations in the tumor-suppressor genes TP53 and retinoblastoma (RB1), occur in nearly all histopathologic types of lung cancer, the frequency and the "timing" of their occurrence...

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PMID: 19914087
DOI: 10.1016/j.critrevonc.2009.10.002

Genes

EGFR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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