Stability of p53 tumor suppressor gene mutations during the process of metastasis and during chemotherapy.

doi:10.1016/0169-5002(95)00548-x

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Article

Stability of p53 tumor suppressor gene mutations during the process of metastasis and during chemotherapy.

Lung cancer (Amsterdam, Netherlands) - 1 Jun 1996

Taniguchi Y, Gemma A, Takeda Y, Takenaka K, Niitani H, Kudoh S, Shimada T

Abstract excerpt

We analyzed 29 pairs of primary and metastatic lung carcinomas obtained at autopsy for mutations in the p53 gene, using the polymerase chain reaction-single strand conformation polymorphism method (PCR-SSCP). We examined the relationship between p53 gene mutations and the development of metastasi...

Topics

Base Sequence
DNA, Neoplasm
Female
Genes, p53
Humans
Lung Neoplasms
Male
Mutation
Polymerase Chain Reaction
Polymorphism, Single-Stranded Conformational

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