Article
Use of a temperature-sensitive mutant to define the biological effects of the p210BCR-ABL tyrosine kinase on proliferation of a factor-dependent murine myeloid cell line.
Oncogene - 1 Jan 1994
Carlesso N, Griffin J D, Druker B J
Abstract excerpt
The Philadelphia chromosome, detected in virtually all cases of chronic myelogenous leukemia, is formed by a reciprocal translocation between chromosomes 9 and 22 that fuses BCR encoded sequences upstream of exon 2 of c-ABL. This oncogene produces a fusion protein, p210BCR-ABL, in which the ABL t...
Topics
- Animals
- Base Sequence
- Cell Division
- Cell Line
- Fusion Proteins, bcr-abl
- Interleukin-3
- Leukemia, Myelogenous, Chronic, BCR-ABL Positive
- Mice
- Molecular Sequence Data
- Mutation
- Phosphorylation
- Protein-Tyrosine Kinases