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Article

Proteolytic activity of novel human immunodeficiency virus type 1 proteinase proteins from a precursor with a blocking mutation at the N terminus of the PR domain.

Journal of virology - 1 Jan 1994

Zybarth G, Kräusslich H G, Partin K, Carter C

Abstract excerpt

The mature human immunodeficiency virus type 1 proteinase (PR; 11 kDa) can cleave all interdomain junctions in the Gag and Gag-Pol polyprotein precursors. To determine the activity of the enzyme in its precursor form, we blocked release of mature PR from a truncated Gag-Pol polyprotein by introducing mutations into the N-terminal Phe-Pro cleavage site of the PR domain. The mutant precursor autoprocessed...

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Identifiers

PMID: 8254734
DOI: 10.1128/JVI.68.1.240-250.1994
PMCID: PMC236283

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