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Article

Properties of avian retrovirus particles defective in viral protease.

Journal of virology - 1 Oct 1990

Stewart L, Schatz G, Vogt V M

Abstract excerpt

The structural and enzymatic components of retroviral cores are formed by proteolytic cleavage of precursor polypeptides, mediated by the viral protease (PR). We constructed an active-site mutation, D37I, in the PR of avian leukosis virus. The D37I mutation was introduced into an infectious DNA clone, and quail cell lines expressing the mutant virus were established. These cell lines produce normal amounts of...

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Identifiers

PMID: 1697912
DOI: 10.1128/JVI.64.10.5076-5092.1990
PMCID: PMC248000

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