Article
Properties of avian retrovirus particles defective in viral protease.
Journal of virology - 1 Oct 1990
Stewart L, Schatz G, Vogt V M
Abstract excerpt
The structural and enzymatic components of retroviral cores are formed by proteolytic cleavage of precursor polypeptides, mediated by the viral protease (PR). We constructed an active-site mutation, D37I, in the PR of avian leukosis virus. The D37I mutation was introduced into an infectious DNA c...
Topics
- Animals
- Avian Leukosis Virus
- Binding Sites
- Cell Line
- Fusion Proteins, gag-pol
- Gene Products, gag
- Microscopy, Electron
- Mutation
- Peptide Hydrolases
- Proviruses
- Quail
- RNA, Viral
- RNA-Directed DNA Polymerase
- Restriction Mapping
- Virion