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Article

Reverse transcriptase and protease activities of avian leukosis virus Gag-Pol fusion proteins expressed in insect cells.

Journal of virology - 1 Dec 1993

Stewart L, Vogt V M

Abstract excerpt

Protease (PR)-defective avian leukosis virus particles display 300-fold-reduced levels of reverse transcriptase (RT) activity relative to wild-type particles. This observation suggests that during virion assembly RT is activated by proteolytic maturation of the Gag-Pol polyprotein precursor. To study the relationship between proteolytic cleavage and RT activation, we subjected PR-defective virion cores to...

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Identifiers

PMID: 7693975
DOI: 10.1128/JVI.67.12.7582-7596.1993
PMCID: PMC238225

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Source receipt: pubmed, retrieved 7 Sept 2026.

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