Reverse transcriptase and protease activities of avian leukosis virus Gag-Pol fusion proteins expressed in insect cells.

doi:10.1128/JVI.67.12.7582-7596.1993

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Article

Reverse transcriptase and protease activities of avian leukosis virus Gag-Pol fusion proteins expressed in insect cells.

Journal of virology - 1 Dec 1993

Stewart L, Vogt V M

Abstract excerpt

Protease (PR)-defective avian leukosis virus particles display 300-fold-reduced levels of reverse transcriptase (RT) activity relative to wild-type particles. This observation suggests that during virion assembly RT is activated by proteolytic maturation of the Gag-Pol polyprotein precursor. To s...

Topics

Animals
Avian Leukosis Virus
Baculoviridae
Cells, Cultured
Defective Viruses
Endopeptidases
Enzyme Activation
Fusion Proteins, gag-pol
Gene Expression Regulation, Viral
Genes, gag
Genes, pol
Moths
Mutation
Protein Processing, Post-Translational
RNA-Directed DNA Polymerase
Recombinant Proteins
Retroviridae Proteins
Virion

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Identifiers

PMID: 7693975
DOI: 10.1128/JVI.67.12.7582-7596.1993
PMCID: PMC238225

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7693975-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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