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Article

A novel protease processing site in the transframe protein of human T-cell leukemia virus type 1 PR76(gag-pro) defines the N terminus of RT.

Journal of virology - 1 Dec 2002

Heidecker Gisela, Hill Shawn, Lloyd Patricia A, Derse David

Abstract excerpt

The genomic RNA of human T-cell leukemia virus type 1 encodes three polyproteins, Gag, Gag-Pro, and Gag-Pro-Pol, which are translated as a result of no, one, and two frameshifts, respectively. In this report we demonstrate that the 77 residues encoded at the C terminus of the Gag-Pro precursor can be collectively detected as an 8-kDa transframe protein (TFP) in virions. Mutant viruses with a C-terminally...

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Identifiers

PMID: 12438640
DOI: 10.1128/jvi.76.24.13101-13105.2002
PMCID: PMC136720

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