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Article

Timeliness of Proteolytic Events Is Prerequisite for Efficient Functioning of the Alphaviral Replicase.

Journal of virology - 15 Jul 2018

Lulla Valeria, Karo-Astover Liis, Rausalu Kai, Saul Sirle, Merits Andres, Lulla Aleksei

Abstract excerpt

Polyprotein processing has an important regulatory role in the life cycle of positive-strand RNA viruses. In the case of alphaviruses, sequential cleavage of the nonstructural polyprotein (ns-polyprotein) at three sites eventually yields four mature nonstructural proteins (nsPs) that continue working in complex to replicate viral genomic RNA and transcribe subgenomic RNA. Recognition of cleavage sites by viral...

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Identifiers

PMID: 29695431
DOI: 10.1128/JVI.00151-18
PMCID: PMC6026757

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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