Role of the avian retroviral protease in the activation of reverse transcriptase during virion assembly.

doi:10.1128/JVI.65.11.6205-6217.1991

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Role of the avian retroviral protease in the activation of reverse transcriptase during virion assembly.

Journal of virology - 1 Nov 1991

Craven R C, Bennett R P, Wills J W

Abstract excerpt

The retroviruses of the avian sarcoma-leukosis virus group synthesize their viral protease (PR) in two precursor forms--as a carboxy-terminal domain of the Gag precursor and as an embedded domain within the Gag-Pol precursor. We have shown previously that the Gag-derived PR is fully capable of processing the Gag precursor in the absence of the embedded PR (R.P. Bennett, S. Rhee, R.C. Craven, E. Hunter, and J.W....

Topics

Amino Acid Sequence
Animals
Avian Sarcoma Viruses
Base Sequence
Cell Line
Cloning, Molecular
Endopeptidases
Enzyme Activation
Fusion Proteins, gag-pol
Genes, gag
Genes, pol

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genetic Vectors

Kinetics

Molecular Sequence Data

Mutagenesis, Site-Directed

Phenotype

Plasmids

Protein Processing, Post-Translational

Source

Open in PubMed Open full text

Identifiers

PMID: 1717718
DOI: 10.1128/JVI.65.11.6205-6217.1991
PMCID: PMC250313

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1717718-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Role of the avian retroviral protease in the activation of reverse transcriptase during virion assembly.PMID 1717718Read ↗

Reverse transcriptase and protease activities of avian leukosis virus Gag-Pol fusion proteins expressed in insect cells.Semantic proximity Read ↗

Avian sarcoma leukemia virus protease linked to the adjacent Gag polyprotein is enzymatically active.Semantic proximity Read ↗

Processing of avian retroviral gag polyprotein precursors is blocked by a mutation at the NC-PR cleavage site.Semantic proximity Read ↗

Proteolytic cleavage at the Gag-Pol junction in avian leukosis virus: differences in vitro and in vivo.Semantic proximity Read ↗

Properties of avian retrovirus particles defective in viral protease.Semantic proximity Read ↗

trans-acting proteins involved in RNA encapsidation and viral assembly in human immunodeficiency virus type 1.Semantic proximity Read ↗

Analysis of cleavage site mutations between the NC and PR Gag domains of Rous sarcoma virus.Semantic proximity Read ↗

An assembly domain of the Rous sarcoma virus Gag protein required late in buddingSemantic proximity Read ↗

Structural requirements for enzymatic activities of foamy virus protease-reverse transcriptase.Semantic proximity Read ↗

Proteolytic activity of novel human immunodeficiency virus type 1 proteinase proteins from a precursor with a blocking mutation at the N terminus of the PR domain.Semantic proximity Read ↗

Soluble expression and enzymatic activity evaluation of protease from reticuloendotheliosis virus.Semantic proximity Read ↗

Overexpression of the HIV-1 Gag-Pol Polyprotein Results in Intracellular Activation of HIV-1 Protease and Inhibition of Assembly and Budding of Virus-like ParticlesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.