Article
Molecular genetics of the human cytochrome P450-dependent monooxygenases.
The Tohoku journal of experimental medicine - 1 Oct 1992
Wolf C R, Smith C A, Smith G, Gough A C, Bryant S, Spurr N K, Harrison D J
Abstract excerpt
In this work, the role of genetic as well as environmental factors in determining cytochrome P450 isozyme levels in man have been studied. Simple DNA based assays for the identification of individuals nulled at the CYP2D6 locus are described and have been applied to investigate whether this gene defect is associated with altered cancer susceptibility. In contrast to literature reports, in no cancer type were poor...
Topics
- Chromosome Mapping
- Cytochrome P-450 Enzyme System
- Disease Susceptibility
- Genotype
- Humans
- Isoenzymes
- Models, Biological
- Mutation
- Neoplasms
- Polymorphism, Genetic