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Article

Mice lacking a CDK inhibitor, p57Kip2, exhibit skeletal abnormalities and growth retardation.

Journal of biochemistry - 1 Jan 2000

Takahashi K, Nakayama K, Nakayama K

Abstract excerpt

p57Kip2, one of the cyclin-dependent kinase (CDK) inhibitors, has been suggested to be a tumor suppressor candidate. To elucidate its biological roles in mouse development and tumorigenesis, we created p57Kip2-deficient mice. The p57Kip2-deficient mice exhibited a cleft palate and defective bone formation resulting in severe dyspnea. Most of the p57Kip2-deficient mice died within 24 h after birth, while about 10%...

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Source

Identifiers

PMID: 10731669
DOI: 10.1093/oxfordjournals.jbchem.a022586

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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