Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Identification and functional characterization of polo-like kinase 2 autoregulatory sites.

Neuroscience - 27 Jan 2012

Rozeboom A M, Pak D T S

Abstract excerpt

Polo family kinases play important roles in cellular proliferation as well as neuronal synaptic plasticity. However, the posttranslational regulation of these kinases is not fully understood. Here, we identified several novel Plk2 phosphorylation sites stimulated by Plk2 itself. By site-directed mutagenesis, we uncovered three additional hyperactivating Plk2 mutations as well as a series of residues regulating...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Catalytic Domain
Share to Chlorocebus aethiops
Share to COS Cells

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hippocampus

Share to Homeostasis

Share to Image Processing, Computer-Assisted

Share to Mutagenesis, Site-Directed

Share to Tandem Mass Spectrometry

Source

Open in PubMed Open full text

Identifiers

PMID: 22100274
DOI: 10.1016/j.neuroscience.2011.11.003
PMCID: PMC3268898

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Identification and functional characterization of polo-like kinase 2 autoregulatory sites.PMID 22100274Read ↗

From Plk1 to Plk5Semantic proximity Read ↗

Role of Plk2 (Snk) in mouse development and cell proliferation.Semantic proximity Read ↗

Single-cell multiome profiling reveals neuronal bias of modulatory role of MeCP2 phosphorylation.Semantic proximity Read ↗

WNKs: protein kinases with a unique kinase domain.Semantic proximity Read ↗

Phosphorylation of MeCP2 at Serine 80 regulates its chromatin association and neurological function.Semantic proximity Read ↗

Inhibition of Polo-like kinase 2 ameliorates pathogenesis in Alzheimer’s disease model miceSemantic proximity Read ↗

The human polo-like kinase, PLK, regulates cdc2/cyclin B through phosphorylation and activation of the cdc25C phosphataseSemantic proximity Read ↗

A large-scale functional RNAi screen reveals a role for CK2 in the mammalian circadian clock.Semantic proximity Read ↗

Epigenetic Inactivation Implies a Tumor Suppressor Function in Hematologic Malignancies for Polo-Like Kinase 2 but not Polo-Like Kinase 3Semantic proximity Read ↗

Polo-like kinase 2 modulates α-synuclein protein levels by regulating its mRNA productionSemantic proximity Read ↗

Differential effects of PER2 phosphorylation: molecular basis for the human familial advanced sleep phase syndrome (FASPS).Semantic proximity Read ↗

Polo-like kinase 2-dependent phosphorylation of NPM/B23 on serine 4 triggers centriole duplication.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.